Combine water and beef base in a 6-quart slow cooker and stir well.
Add prime rib, potatoes, frozen vegetables, red wine, onion, ketchup, celery, carrots, garlic, parsley, thyme, salt, and pepper. Cook on Low until vegetables are tender, 6 to 8 hours.
I use LeGout(R) beef base from a restaurant supply store rather than beef broth or beef boullion. I find it adds better flavor. Adjust amount to your taste.
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