Preheat oven to 375degrees F (190 degrees C).
Bring a large pot of lightly salted water to a boil. Add pasta and cook for 8 to 10 minutes or until al dente; drain.
In a large saucepan over medium heat, melt 2 tablespoons butter.Whisk in flour and cook, stirring, 1 minute.A little at a time, whisk in milk, mustard, salt, pepper and hot sauce.Bring to a gentle boil, stirring constantly.Boil 1 minute, then remove from heat and whisk in pepperjack, Cheddar and Parmesan until smooth.Stir in cooked pasta and pour into shallow 2 quart baking dish.
Melt remaining 2 tablespoons butter.Stir in bread crumbs and chili powder.Sprinkle over macaroni mixture.
Bake in preheated oven 30 minutes.Let stand 10 minutes before serving.
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